I have been diagnosed with depression, as part of a diagnosis of Bipolar II, since I was 10 years old. There have been some good years and bad years, on and off with medication, but obviously, there’s no cure. Some people only suffer with depression as a a response to a stimulus, but others live with a lifelong illness.
Some medications have worked for me. Sometimes, they do not work in a few years; my body chemistry has changed, my needs have changed.
Therapy has done a little, but not much, since the most effective therapists I see end up with more urgent callings like hospice work or research.
Surrounding myself with people who are patient and positive does the most, as well as avoiding everything which makes me feel negativity.